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The Data Behind Kratom’s Mitragynine and 7-Hydroxymitragynine

Have you ever heard of Kratom Mitragynine and 7-Hydroxymitragynine? These compounds are the subject of much research as they have been found to have various potential benefits. This article will explore the data behind these compounds and discuss Kratom’s potential health benefits and side effects.

Introduction to Mitragynine and 7-Hydroxymitragynine

Mitragynine and 7-hydroxy mitragynine are the two primary active alkaloids in the Southeast Asian plant Mitragyna speciosa, better known as Kratom. These alkaloids have attracted attention due to their unique pharmacological properties, which include analgesic (painkilling), antitussive (cough-suppressing), antidiarrheal, adrenergic (stress-reducing), and antimalarial effects.

Interestingly, while Mitragynine is structurally similar to other opioid alkaloids, such as codeine and morphine, it does not appear to interact with the same brain receptors as these drugs. Instead, Mitragynine seems to selectively bind to delta opioid receptors, which explains its painkilling effects. 7-Hydroxymitragynine, on the other hand, is a more potent agonist of the mu-opioid receptor, which explains its more substantial analgesic effects.

While there is still much research to be done on the exact mechanisms of action of these alkaloids, they show promise as potential treatments for a variety of conditions, including pain, anxiety, and drug addiction.

Overview of the Benefits of Mitragynine and 7-Hydroxymitragynine

Mitragynine and 7-hydroxymitragynine are the most critical alkaloids in the Mitragyna speciosa plant. They are responsible for the plant’s unique pharmacological effects.

Mitragynine is the primary alkaloid in M. speciosa (Kratom). It is responsible for the plant’s sedative, analgesic, and anti-inflammatory effects. 7-Hydroxymitragynine is a more potent alkaloid than Mitragynine and is responsible for the plant’s anxiolytic and antidepressant effects.

The beneficial effects of Mitragynine and 7-hydroxymitragynine in the Kratom leaf have been extensively studied in animal models. These studies have shown that these alkaloids can produce profound changes in mood, perception, and physiology.

In mice, for example, Mitragynine has been shown to reduce pain by acting on the pain pathway at both the spinal cord and brain levels. 7-Hydroxymitragynine has also been shown to reduce pain, but it does so by a different mechanism than Mitragynine. In rats, 7-hydroxymitragynine is significantly more potent than morphine at reducing pain.

The Science Behind the Benefits: How These Compounds Work

These two compounds, Mitragynine and 7-hydroxymitragynine, are the main active constituents of the plant Mitragyna speciosa, better known as Kratom. These molecules have various effects on the brain, including pain relief, anxiolytic (anti-anxiety) properties, and even mild sedation. Let’s take a closer look at how they work.

Mitragynine works primarily by binding to delta opioid receptors in the brain, which are responsible for pain relief. It also binds to kappa opioid receptors associated with anxiety reduction. Mitragynine also inhibits the uptake of noradrenaline and serotonin, two neurotransmitters involved in mood regulation.

7-Hydroxymitragynine is structurally similar to Mitragynine but is many times more potent. It also binds to delta and kappa opioid receptors but with much higher affinity than Mitragynine. Additionally, it has been shown to activate supraspinal mu-opioid receptors, which are responsible for pain relief. This compound also inhibits the uptake of noradrenaline and serotonin.

Possible Side Effects of Mitragynine and 7-Hydroxymitragynine

The most common side effects of Mitragynine and 7-hydroxymitragynine are nausea, vomiting, diarrhea, constipation, dizziness, headache, and dry mouth. These side effects are typically mild and resolve independently, without medical intervention.

More severe side effects have been reported with higher doses of these compounds, including seizures, liver toxicity, and death. These more severe side effects are rare and typically only occur in people taking very high doses of the compounds or with pre-existing medical conditions that make them more susceptible to adverse reactions.

Suppose you experience any side effects while taking Mitragynine or 7-hydroxymitragynine. In that case, it is essential to consult with a healthcare professional to ensure that the benefits of these Kratom compounds outweigh the risks.

Kratom Tips for Safe Use

First, always consult your doctor before taking any herbal supplements, including Kratom.

When using Mitragynine and hydroxymitragynine, it is crucial to be aware of their potential side effects. While these substances in Kratom have been shown to provide numerous benefits, they can also cause adverse reactions in some people. It is, therefore, essential to follow the proper safety precautions when using them.

Some of the most common side effects of Mitragynine and hydroxymitragynine include nausea, vomiting, diarrhea, dizziness, and headaches. These substances can also cause constipation and dry mouth. If you experience any of these Kratom side effects, it is essential to drink plenty of fluids and seek medical attention if necessary.

It is also important to know that the Mitragynine and hydroxymitragynine in Kratom can interact with other medications. Therefore, if you are taking any prescription or over-the-counter drugs, you must speak with your healthcare provider before using these substances.

Generally, starting your Kratom regime with a low dose is always best. When using Mitragynine or hydroxymitragynine, you can increase the quantity gradually as needed. However, it is essential not to take more than the recommended amount as this could lead to serious side effects. Suppose you have questions about the proper dosage or use of these substances. In that case, it is best to speak with a healthcare professional before starting treatment.


In conclusion, Mitragynine and 7-hydroxymitragynine are compounds with various beneficial effects on the human body. They have been studied extensively and proven safe and effective in treating various health ailments. It is important to remember that although these compounds can relieve specific conditions, it is always best to consult your healthcare provider before starting any new supplement or medication regimen. Additionally, as more research is conducted into the potential benefits of these compounds, there may be additional applications for their use which could further improve our overall well-being.

If you’re thinking about trying kratom for its possible benefits, you can try our Sentient Kratom brand here.

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Sweet Southern Trading retains the right to not ship to any states or territories where local laws conflict with H.R. 2: The Agricultural Improvement Act of 2018, also known as the 2018 Farm Bill. Due to Δ8THC either illegal or not explicitly legal according to state laws, this product does not ship to the following states: Alaska, Arizona, California, Colorado, Delaware, Idaho, Iowa, Montana, Nevada, North Dakota, Rhode Island, Utah, and Vermont.

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